Leave on for at least 2 hours, ideally overnight, allowing the microneedles to fully dissolve and release the actives deeper into the skin where they can be most effective.
For best results, use two-three times per week for from 2 weeks for blemishes and 6-8 weeks for dark spots, or until desired result is an achieved. To avoid risk of sensitivity, do not use more than 3 times per week or within 24 hours of previous application.